|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, LAD1 predicts poor patient prognosis and is highly expressed in aggressive subtypes of breast cancer characterized as integrative clusters 5 and 10, which partly correspond to triple-negative and HER2-positive tumors.
|
29382783 |
2018 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, LAD1 predicts poor patient prognosis and is highly expressed in aggressive subtypes of breast cancer characterized as integrative clusters 5 and 10, which partly correspond to triple-negative and HER2-positive tumors.
|
29382783 |
2018 |
|
Junctional Epidermolysis Bullosa
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus, these studies demonstrate that: (i) LAD-1 and BP180 are normally expressed in all subtypes of JEB except GABEB, (ii) the majority of GABEB patients show absent or near absent expression of both LAD-1 and BP180 but normal expression of laminin-5, and (iii) a smaller subset of GABEB patients show normal LAD-1 and BP180 expression but express persistent but reduced levels of laminin-5.
|
9284104 |
1997 |
|
Junctional Epidermolysis Bullosa
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that the absent expression of LAD-1 is observed in a BPAG2-deficient generalized atrophic benign epidermolysis bullosa patient with mutations in both alleles of COL17A1, and not in other epidermolysis bullosa subtypes.
|
9804354 |
1998 |
|
Epidermolysis Bullosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that the absent expression of LAD-1 is observed in a BPAG2-deficient generalized atrophic benign epidermolysis bullosa patient with mutations in both alleles of COL17A1, and not in other epidermolysis bullosa subtypes.
|
9804354 |
1998 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, LAD1 predicts poor patient prognosis and is highly expressed in aggressive subtypes of breast cancer characterized as integrative clusters 5 and 10, which partly correspond to triple-negative and HER2-positive tumors.
|
29382783 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that the relative expression level of miR-650 was significantly higher in LAD tissues than in corresponding nontumor tissues and high level of miR-650 expression was found to be significantly associated with high incidence of lymph node metastasis, advanced clinical stage and poor prognosis of LAD patients.
|
23991130 |
2013 |
|
Congenital leukocyte adherence deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukocyte adhesion deficiency or LAD is a congenital immunodeficiency disease characterized by recurrent bacterial infections in which the leukocytes from affected children fail to adhere to endothelial cells and migrate to the site of infection due to heterogeneous defects in the leukocyte integrin CD18 subunit.
|
9473215 |
1998 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Univariate analyses and predefined multivariable models were performed to determine the association between cardiac biomarkers (positive troponin [troponin ≥0.1 ng/mL] and LAD on transthoracic echocardiogram) and LVO adjusting for demographic factors (age and sex), risk factors (hypertension, diabetes, hyperlipidemia, history of stroke, congestive heart failure, coronary heart disease, and smoking), and atrial fibrillation (AF).
|
30898447 |
2019 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Patients with insulin deficient diabetes (CPEP<sub>low</sub>; n = 503) had higher HbA<sub>1c</sub> but otherwise lower cardiometabolic risk (lower BMI, BP, LDL, triacylglycerol, and ALT, and higher HDL) than both patients with latent autoimmune diabetes of adults (LADA defined as GAD<sub>pos</sub>CPEP<sub>high</sub>; n = 327) and patients with type 2 diabetes (GAD<sub>neg</sub>CPEP<sub>high</sub>; n = 3544).
|
28987750 |
2017 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Although the exact pathogenesis of LADA is unknown and questions the role of autoimmunity in beta cell failure, the familial aggregation of these two forms of diabetes underlines the existence of common roots, i.e. immune mechanisms and genetic susceptibility.
|
17395515 |
2007 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
This study aims to explore whether diabetes mellitus from T1DM, through LADA, to T2DM presents a continuous spectrum in terms of HLA-DQ genetic background.
|
19120276 |
2008 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Ninety-eight patients with type 1 diabetes (median age, 35 years; range, 9-89 years and 51 patients with latent autoimmune diabetes (LADA; median age, 48 years; range, 19-79 years) were compared with 113 healthy control patients (median age, 35 years; range, 19-65 years) to study the importance of MICA-microsatellite polymorphism and HLA-DR-DQ as genetic risk factors for diabetes.
|
12941547 |
2003 |
|
Diabetes
|
0.060 |
Biomarker
|
disease |
BEFREE |
Patients with insulin deficient diabetes (CPEP<sub>low</sub>; n = 503) had higher HbA<sub>1c</sub> but otherwise lower cardiometabolic risk (lower BMI, BP, LDL, triacylglycerol, and ALT, and higher HDL) than both patients with latent autoimmune diabetes of adults (LADA defined as GAD<sub>pos</sub>CPEP<sub>high</sub>; n = 327) and patients with type 2 diabetes (GAD<sub>neg</sub>CPEP<sub>high</sub>; n = 3544).
|
28987750 |
2017 |
|
Diabetes
|
0.060 |
Biomarker
|
disease |
BEFREE |
Univariate analyses and predefined multivariable models were performed to determine the association between cardiac biomarkers (positive troponin [troponin ≥0.1 ng/mL] and LAD on transthoracic echocardiogram) and LVO adjusting for demographic factors (age and sex), risk factors (hypertension, diabetes, hyperlipidemia, history of stroke, congestive heart failure, coronary heart disease, and smoking), and atrial fibrillation (AF).
|
30898447 |
2019 |
|
Diabetes
|
0.060 |
Biomarker
|
disease |
BEFREE |
Ninety-eight patients with type 1 diabetes (median age, 35 years; range, 9-89 years and 51 patients with latent autoimmune diabetes (LADA; median age, 48 years; range, 19-79 years) were compared with 113 healthy control patients (median age, 35 years; range, 19-65 years) to study the importance of MICA-microsatellite polymorphism and HLA-DR-DQ as genetic risk factors for diabetes.
|
12941547 |
2003 |
|
Diabetes
|
0.060 |
Biomarker
|
disease |
BEFREE |
Although the exact pathogenesis of LADA is unknown and questions the role of autoimmunity in beta cell failure, the familial aggregation of these two forms of diabetes underlines the existence of common roots, i.e. immune mechanisms and genetic susceptibility.
|
17395515 |
2007 |
|
Leukocyte adhesion deficiency type 1
|
0.050 |
Biomarker
|
disease |
BEFREE |
Clinically, patients with LAD II suffer not only from a less severe form of infectious episodes resembling the moderate phenotype of LAD I but also from severe psychomotor and growth retardation.
|
19437145 |
2010 |
|
Leukocyte adhesion deficiency type 1
|
0.050 |
Biomarker
|
disease |
BEFREE |
While in LAD I the integrin family is defective, in LAD II the selectin system is involved.
|
11213799 |
2000 |
|
Congenital disorder of glycosylation, type 2C
|
0.050 |
Biomarker
|
disease |
BEFREE |
Following the recent recommendations for the nomenclature for CDG, this new type is classified as CDG-IIc (formerly LAD II).
|
11326280 |
2001 |
|
Atrial Fibrillation
|
0.040 |
Biomarker
|
disease |
BEFREE |
Univariate analyses and predefined multivariable models were performed to determine the association between cardiac biomarkers (positive troponin [troponin ≥0.1 ng/mL] and LAD on transthoracic echocardiogram) and LVO adjusting for demographic factors (age and sex), risk factors (hypertension, diabetes, hyperlipidemia, history of stroke, congestive heart failure, coronary heart disease, and smoking), and atrial fibrillation (AF).
|
30898447 |
2019 |
|
Atrial Fibrillation
|
0.040 |
Biomarker
|
disease |
BEFREE |
The number of GT repeats, combined with LAD, was significant for predicting AF recurrence after catheter ablation (p = 0.01).
|
23437133 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
We concluded that both heterozygosity for MICA5.0/5.1 and HLA-DR3-DQ2/DR4-DQ8 are separate risk factors for LADA, but that heterozygosity for HLA-DR3-DQ2/DR4-DQ8 and DR4-DQ8 alone are most important for type 1 diabetes.
|
12941547 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
This report clearly illustrates the differences in terms of autoimmunity (prevalence and titer of GAD and IA2 antibodies) and HLA class II genotype between patients with LADA and those with juvenile type 1 diabetes.
|
17395515 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
We genotyped allelic frequencies of 1 protective and 3 risk-associated PTPN22 variants in 156 Czech LADA patients, 194 type 2 diabetes mellitus patients with LADA-like progression to insulinotherapy and 324 type 1 diabetes mellitus patients, and subsequently examined the associations of PTPN22 variants with the expression of autoantibodies and other clinical features of LADA.
|
29895027 |
2018 |